Curcumin, a BCS Class IV drug exhibiting poor solubility possesses its wound healing property owing to its anti-inflammatory, antioxidant and anti-infectious activities. The objective of the current study was to load Curcumin on porous silica Aeroperl ® 300 Pharma for solubility enhancement. The Curcumin loaded silica was further incorporated into a Chitosan-Xanthan gum polyelectrolyte complex gel with final application for wound healing activity. Curcumin was loaded on Aeroperl® 300 Pharma in 3 ratios of 1:1, 1:2 and 1:5 and the Curcumin loaded silica was evaluated for solubility, drug contentand in vitro drug release in Phosphate buffered saline PBS pH 7.4. Curcumin loaded silica in ratio 1:5 was found to show highest solubility of 0.68±0.02 µg/ml in PBS pH 7.4 and drug content of 88.3±0.17% and in vitro drug release