Unlock the secrets of musical Ingenuity. Music has healing power, to act as a stimulus and diverting feelings of anxiety, stress, and fear thereby promoting relaxation. Objectives: study was to assess the effect of Music therapy on anxiety and pain among patients undergoing transfemoral coronary angiography. Methods. In this pilot study, 40 subjects undergoing elective transfemoral Coronary angiography post-test only control design was used. The data collected for a period of Ten weeks. With the purposive sampling technique 40 samples were selected, 20 were assigned to the experimental group and 20 in control group. The demographic data was recorded from the patients undergoing transfemoral Coronary angiography. Indian Carnatic system Raga Neelambari classical music was administered for 15 minutes in the experimental group during the transfemoral coronary angiography. Routine treatment was facilitated to the patients in the control group. After 15 minutes intervention the level of anxiety score was assessed using the state Hamilton anxiety rating scale in each group. The levels of pain were measured by Wong baker pain scale. Result: The Average anxiety score in Experimental group pretest was mean 24.4 Sd 3.8 which reduced to mean13.6 Sd 2.0 in post-test. T value for this test was 11.6 with 19 degrees of freedom. Corresponding p-value was small (less than 0.05), two sample t-test were used for the comparison of change in anxiety score among patients undergoing coronary angiography in experimental and control group. Average change anxiety score in experimental group was 10.8 which was -0.9 in control group. T-value for this test was 12.4 with 38 degrees of freedom. Average change in anxiety score in experimental group was significantly higher than that in control group. In experimental group, at first, 90% of the patients had mild pain and 10% of them had moderate pain. In control group, at first hour, 45% of them had moderate pain and 55% of them had severe pain. At third hour, in experimental group, all of them had mild pain. and in control group, all of them had moderate pain. At sixth hour, in experimental group, none of them had pain. At sixth hour, in control group, all of them had mild pain. The pain among patients in experimental and control group was compared using Fisher’s exact test The levels of pain and anxiety. were relatively low during the transfemoral coronary angiography period. Corresponding p-value was small (less than 0.05) Conclusion: Hence it is concluded music therapy is an effective therapeutic intervention in reducing the level of anxiety and Pain among patients undergoing Coronary Angiography.