Creutzfeld jacob disease (CJD) is a prion, neuro-degenerative disorder. This disease is rapidly progressive and always fatal. Infection with this disease leads to death usually within 1 year of onset of illness. Here, we present a case report of a 50 years old female patient, who came to the psychiatry outpatient department with the complaints of poor self-hygiene, psychomotor retardation and rigidity in all limbs. Her differential diagnosis was kept as catatonic schizophrenia and meningitis; which was later confirmed as Creutzfeld jacob disease (CJD) by a detailed CSF analysis and neurological examination. Though CJD is not a common disease, it should be considered as differential diagnosis whenever neuropsychological manifestations, especially progressive decline in cognition, along with symptoms such as psychomotor retardation and hallucinatory behaviour are present.