Background: Heart failure (HF) is a major health problem with varying epidemiology and Article History Volume 6, Issue Si4, 2024 Received: 01 June 2024 Accepted : 30 June 2024 Doi: 10.48047/AFJBS.6.Si4.2024.16 97 1 709 outcomes across different regions. This study aimed to investigate the clinical profile, risk factors, and outcomes of heart failure patients admitted to a tertiary care hospital in central India. Methods: A prospective cross-sectional study was conducted on 120 heart failure patients admitted to the Department of General Medicine,Chirayu Medical College & Hospital from October 2023 to March 2024. Demographic, clinical, and outcome data were collected and analyzed. Results: The mean age of the patients was 62±14 years, with a male predominance (65%). The most common risk factors were hypertension (78%), smoking (45%), diabetes mellitus (38%), and alcohol consumption (35%). Dyspnea on exertion (92%), orthopnea (78%), and pedal edema (72%) were the most frequent presenting symptoms. The in-hospital mortality rate was 8%, with septic shock and acute kidney injury being independent predictors of mortality. Conclusions: Heart failure was more prevalent in elderly males, with hypertension being the most common risk factor. The in-hospital mortality rate was relatively high, emphasizing the need for early recognition and management of high-risk patients.