Nanotechnology has been widely studied for its use in creating colloidal silver nanoparticles (AgNPs), which have gained considerable interest for their exceptional antibacterial and anti-inflammatory effects. Silver nanoparticles (AgNPs) are synthesised by a range of processes, including physical, chemical, and biological procedures. Out of these methods, the green synthesis technique has become popular since it uses plant extracts and has advantages such as being environmentally friendly, cost-effective, and capable of producing nanoparticles that are very stable and biologically active. The Rhodiolarosea plant, renowned for its medicinal benefits, is an exceptional resource for the environmentally friendly production of silver nanoparticles (AgNPs). These nanoparticles have strong anti-inflammatory properties, making them excellent candidates for the treatment of disorders like burn wounds, where inflammation and infection are significant issues. The compact dimensions and expansive surface area of AgNPs enable them to easily infiltrate microbial cells, hence augmenting their antibacterial potency and diminishing inflammation. Moreover, the bioactive constituents included in Rhodiolarosea extract enhance the stability and efficacy of the synthesised nanoparticles. Characterisation methods, including UV-Vis spectroscopy, TEM, SEM, and XRD, provide evidence of the effective synthesis and favourable characteristics of AgNPs. Preclinical studies have showed encouraging results in the use of AgNPs integrated into ointments for treating burn wounds. These studies have shown a substantial decrease in inflammation and improved wound healing. Further investigation and refinement of eco-friendly synthesis techniques for AgNPs have significant prospects in the development of cutting-edge, secure, and efficient therapeutic agents in the healthcare sector.