A palatogingival groove is a developmental defect that increases the risk of a serious periodontal disease developing in the affected tooth. Due to the interdisciplinary nature of diagnosis and treatment planning, these grooves frequently pose a clinical problem. The effective treatment of a left maxillary lateral incisor with a deep palatogingival groove, alarge periodontal pocket, and pulp necrosis of the affected tooth is described in this casereport. A combination of endodontic therapy, periodontal therapy, and a period on talregenerative method using a protein complex generated from the enamel matrix (Emdogain; Straumann, Basel, Switzerland) were used in the collaborative management process. Thetooth lesion healed even though a bad prognosis was anticipated. The report additionally examines the reasoning behind the various therapy approaches.