Relevance:Skin diseases and scarring are a significant medical and social problem, impacting patients' quality of life. The drug "KARTAMSCAR" combines traditional ingredients described by Ibn Sina—propolis, safflower, and cottonseed oil—with modern pharmaceutical technologies. Objective: To evaluate the comparative effectiveness of standard therapy and combination therapy using "KARTAMSCAR" in patients with post-acne, hypertrophic scars, and stretch marks. Materials and methods:The study involved 58 patients aged 20 to 60 years. Patients were divided into two groups: a control group (standard treatment) and an intervention group (standard treatment + KARTAMSCAR). Efficacy was assessed using the POSAS and VAS scales after 4 and 8 weeks. Results: The intervention group showed a statistically significant improvement in scar tissue: the average POSAS score decreased by 45.7% compared to 21.4% in the control group (p<0.01). There were no side effects. Conclusions: The use of KARTAMSCAR as part of a combination therapy significantly increases the effectiveness of skin disease treatment, improving skin elasticity, color, and texture.