INTRODUCTION: OSMF stiffens oralmucosa, reducing mouth opening and causing burning sensation, affecting oral health and overall quality of life. Therapies such as intralesional injections stimulate tissue growth. The use of lasers is known to alleviate OSMF symptoms.The objective of this study was to evaluate and compare the efficacy of Low-level laser therapy with intralesional injections and intralesional injection alone for the treatment of OSMF. METHODOLOGY: 20 individuals with OSMF were randomly split into two groups of ten each to evaluate, changes in mouth opening, and pain response to treatment. One groupreceived solely Intralesional Injections, while second group received both Intralesional Injections and Low-level laser therapy. RESULT: Regarding mouth opening, the Intralesional Injection + LLLT group exhibited notably superior progress, compared to the Intralesional Injection alone group. However, no significant contrast was observed between the groups in terms of pain sensation. CONCLUSION: The findings of this study affirm that combining LLLT with intralesional injections is a viable treatment approach for patients with OSMF.