Objective: The main objective of this study was to compare the immediate biomechanical (increase extensibility of tissues for increase of range of motion) and systemic (decrease in pain level) effects of active release technique and myofascial release on thoracic spine. Methodology: A quantitative double blind study was conducted by following a research design of randomized control trial. Screen out total 180 students from DPT department of LIMS College by using NPRS, thoracic ROM (digital Inclinometer application), occiput to wall distance (OWD) and spine functional index questionnaire. There were 40 students meet inclusion exclusion criteria. They were equally divided into two groups, group 1(n=20) and group 2(n=20). Group 1 receives active release technique and Group 2 receives myofascial release technique. Both groups receives infrared as baseline treatment. Measurements were recorded before and immediate after application of treatment. Statistical analysis was performed on SPSS version 22. Results: Wilcoxon signed ranks test, Mann-Whitney U test, independent sample t test and paired sample t test was used to compare the values. Both treatment options show significant results but when compare both groups for these effects then results were non-significant. Conclusions: Improvement for thoracic pain, thoracic ROM and occiput to wall distance was found in both myofascial release technique and active release technique groups. However, no significant difference was observed between both groups.