Mandibular fractures are among the most common facial injuries requiring surgical intervention. The study aims to compare the efficacy of locking miniplates versus conventional miniplates in mandibular fracture fixation. A randomized controlled trial was conducted on 80 patients with mandibular fractures, divided into two groups: Group A (locking miniplates) and Group B (conventional miniplates). Clinical parameters, including stability, postoperative complications, and functional outcomes, were assessed over six months. Statistical analysis revealed a significantly lower incidence of postoperative infection, screw loosening, and malocclusion in the locking miniplate group (p < 0.05). Additionally, bone healing was significantly faster in Group A, as indicated by radiographic evidence at 8 and 12 weeks (p < 0.01). The results suggest that locking miniplates provide superior biomechanical stability and reduce hardware-related complications compared to conventional miniplates. This study highlights the advantages of locking miniplates in optimizing mandibular fracture management and provides evidence for their preference in clinical practice.