This study aims to compare the efficacy and safety of adding dexmedetomidine to levobupivacaine for brachial plexus block (BPB). BPB is a common regional anesthesia technique used in upper limb surgeries, providing targeted pain relief with fewer systemic side effects than general anesthesia. Levobupivacaine, a long-acting local anesthetic, is favored for its prolonged analgesic effects and reduced cardiotoxicity. However, enhancing the duration and quality of anesthesia remains a clinical goal. Dexmedetomidine, an alpha-2 adrenergic agonist, has shown potential in enhancing nerve blocks when used as an adjunct, owing to its sedative, analgesic, and anxiolytic properties. This study evaluates whether the combination of dexmedetomidine with levobupivacaine offers superior analgesia, quicker onset, and extended duration compared to levobupivacaine alone. Additionally, it assesses the safety profile of this combination by monitoring side effects and adverse reactions. Through a randomized controlled trial, the study aims to provide robust evidence on the clinical benefits and risks of this combination, potentially guiding anesthesia practices towards improved patient outcomes in surgical settings. The findings could lead to enhanced perioperative pain management and reduced opioid reliance, ultimately improving the quality of care in regional anesthesia.