Background and Aim: Hemodynamic responses [Systolic blood pressure (SBP); Diastolic blood pressure (DBP); mean arterial pressure (MAP); Spo2] during laryngoscopy and intubation are a significant concern for the anesthesiologist. This study was aimed to compare the effects of nebulisation of Dexmedetomidine and Lignocaine and plain lignocaine for control of hemodynamic response to laryngoscopy and intubation when used in combination or alone. Materials and Methods: This was a prospective Randomised double-blind study where in 60 patients undergoing surgeries under general anaesthesia were allocated into two groups.1) Group A- will receive pre-operative nebulisation with Dexmedetomidine + Lignocaine. 2) Group B- will receive pre-operative nebulisation with lignocaine aloneHemodynamic response to the laryngoscope and intubation was compared and recorded. Results:The heart rate, SBP, DBP, and spo2, MAP was very well controlled in group A in comparison with group B which is statistically significant (P value: 0.011, 0.031, 0.031& 0.003 respectively). Conclusion: In comparison to nebulisation lignocaine alone, the combination of nebuliseddexmedetomidine and lignocaine significantly attenuates the pressure response during laryngoscopy and intubation without any hemodynamic side effects.