The highly serious parasite illness helminthiasis is brought on by anthelmintic medications, demonstrating their impact on the human body and its normal functions. After doses were administered, the earthworms' paralysis and death time were calculated. The anthelmintic activity of the earthworms revealed that they died and became paralyzed more quickly. We can infer that because earthworms are easy to handle, noticeable, and adaptable to lab settings, they can be employed successfully in anthelmintic activity studies. It is not possible to adjust the evaluation of anthelmintic activity of any medicine under artificial laboratory settings when it is done using isolated worms from nature. The current investigation of anthelmintic activity suggests a novel approach using lab-cultured earthworms.We compared the commercial formulation of albendazolesuspension with the anthelmintic activity of a combination of Syzygiumaromaticumand Zingiberofficinales.The combination of Syzygiumaromaticum bud powder extract and Zingiberofficinales powder resulted in a significantly shorter period for the earthworms to become paralyzed and die. This new dose form shows potential as a preventive measure against worm infections in young patients.