Background Javanese cardamom fruit (Amomum compactum Sol. Ex Maton), from the Zingiberaceae family, has long been used as an herbal plant. Purpose The aim of the research was to evaluate the standardization of Javanese Cardamom simplicia and the profile of its extract compounds in water, n-hexane and its essential oil. Methods Research methods include making simplicia powder, simplicia standardization, phytochemical screening, Total Phenolic Content, Total Flavonoid Content, Total Terpenoid Content, and simplicia extraction in water and n-hexane solvents using maceration-ultrasonic analyzed by LC-MS, and CEO isolation using steam distillation analyzed by GC-MS. Results The results of the simplicia standardization research showed Water Content of 7.74 ± 0.11%, Ash Content of 9.69 ± 0.03%, Total Plate Count of 5.4x106 cfu/g, Total Fungal Count of 2.3x106 cfu/g, Water-Soluble of Extract 1.79±0.11, Ethanol-Soluble Extract of 0.47±0.15, phytochemical screening contained triterpenoids, steroids and alkaloids. Total Phenolic Content of 1.48±0.53 (mgGAE/g), Total Flavonoid Content of 0.53±0.07 (mgQE/g), Total Terpenoid Content 37.12±0.02 (mg/g). The secondary metabolite profile in water includes polyphenols (flavonoids, simple phenols, tannins, oxaspiro-organic), diarylheptanoids and terpenoids . In the n-hexane solvent there are diarylheptanoids, terpenoids (mono-,sesqui-,di-,triterpenoids), and polyphenols (flavonoids and simple phenols). CEO contains mono- and sesqui-terpenoid. Conclusion The conclusion is that the standardization of simplicia has met FHI standards; Secondary metabolite profile in water solvent extracted polar compounds, i.e. polyphenols group (flavonoids, simple phenols, tannins, oxaspiro-organic) then semi-non-polar, i.e. diarylheptanoids, terpenoids; in n-hexane solvent extracted nonpolar compounds, i.e. diarylheptanoids, terpenoids, and CEO only terpenoids.