Canagliflozin, an inhibitor of the Sodium glucose transport protein (SGLT2), represents a pivotal advancement in the management of type 2 diabetes mellitus. SGLT2 inhibitors is successfully reduced the risk of heart failures in patient with type 2 diabetes Mellitus. This comprehensive review aims to provide a detailed examination of the analytical methods employed for the quantitative and qualitative analysis of Canagliflozin such as chromatography, spectrophotometry, and hyphenated techniques, such as Liquid chromatography with tandem mass spectrometry (LC-MS/MS) and Ultra performance liquid chromatography with tandem mass spectrometer (UPLC-MS)as well as emerging methods like capillary electrophoresis (CE) and electrochemical methods for the analysis of Canagliflozin. By consolidating and evaluating the current state-of-the-art analytical methodologies for Canagliflozin, this review seeks to provide valuable insights for researchers, analysts, and practitioners involved in drug development, regulatory compliance, and clinical investigations. Ultimately, a comprehensive understanding of these analytical methods is essential for ensuring the efficacy, safety, and quality of Canagliflozin-based therapies. It was concluded that many methods for determination of Canagliflozin have been reported. Methods for the analysis of active and inactive metabolites of Canagliflozin also been reported. Some articles related to the determination of Canagliflozin alone or in combination with metformin in pharmaceutical dosage forms have been mentioned.