Biomedical waste (BMW) management is critical for healthcare operations due to its significant implications for environmental and public health. Despite regulatory guidelines, disparities in the knowledge, attitudes, and practices. (KAP) of healthcare professionals regarding BMW management persist. This comprehensive study reviews literature from 2016 to 2023 to assess these KAP dynamics and identify areas requiring targeted interventions. Through the analysis of twelve pertinent studies, this research highlights the influential roles of education, training, and institutional support in shaping KAP levels. Key findings indicate significant variations in healthcare professionals' knowledge and practices, often influenced by their educational background, training adequacy, and the presence of robust institutional policies. Higher education and comprehensive training programs are consistently associated with improved knowledge and practices in BMW management. However, even well-educated and trained healthcare workers exhibit varied attitudes towards BMW management, largely affected by the support and resources provided by their institutions. The study underscores the critical need for continuous education and regular training to keep healthcare workers updated on best practices and regulatory changes. It emphasizes that healthcare facilities with strong administrative support and clear waste management protocols demonstrate higher compliance levels. Conversely, facilities lacking these resources struggle with effective waste management. The broader implications of these findings highlight the necessity for evidence-based interventions. Tailored educational programs addressing specific gaps identified in different healthcare settings are crucial. Additionally, stringent regulatory enforcement and support from policymakers are essential to ensure healthcare facilities adhere to established BMW management guidelines. By synthesizing insights from diverse studies, this research provides a comprehensive overview of current BMW management practices, identifying prevalent trends and critical gaps. It advocates for proactive measures, including tailored training programs and stringent regulatory frameworks, to enhance compliance with BMW protocols. The study contributes to a deeper understanding of the complexities surrounding BMW management and underscores the need for continuous education, training, and institutional support.Ultimately, effective BMW management is vital for protecting public health and ensuring environmental sustainability. Through concerted efforts and informed interventions, healthcare professionals can significantly contribute to safer and more sustainable BMW management practices, thereby safeguarding both human health and environmental integrity.