ISSN : 2663-2187

Comprensive review on Pathophysiology and Emerging Treatment of Polycystic Ovarian Syndrom

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Sumit S Mutha, Dr. Manish R. Bhise
» doi: 10.48047/AFJBS.4.4.2022.763-778

Abstract

Polycystic ovarian syndrome (PCOS) is a heterogeneous endocrine disorder distinguished by the manifestation of ovarian cysts, anovulation, and endocrine variation that severely impact the life of a woman1 (Escobar-Morreale, 2018, Franks, 1995) The disturbance in the reproductive hormones like LH, FSH, estrogen, testosterone interrupts the normal menstrual cycle and would lead to oligomenorrhoea, amenorrhea like irregularitie According to the World Health Organization (WHO) estimation revealed over 116 million women (3.4%) are affected by PCOS worldwide (Bharathi et al., 2017) . PCOS is diagnosed with hyperandrogenism, menstrual irregularities, and varying size of cysts in ovaries, although substantial differences exist between individuals. This multifactorial condition initially develops in adolescents who are at high risk for the emergence of several comorbidities including obesity, type II diabetes, infertility, endometrial dysplasia, cardiovascular disorders, and psychotic disorders (El Hayek et al., 2016, Goodarzi et al., 2011)

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