This study aims outlines a comprehensive methodology for studying Human GRK2 in complex with G-beta-gamma in cardiovascular disease. g protein-coupled receptor kinases (GRKs) play crucial roles in receptor desensitization. changes in GRK expression have emerged as prominent factors in cardiovascular diseases. Study aims to explore the evolving understanding of GRKs in the context of cardiovascular diseases. The 3D structure of 3KRX is translated into its amino acid sequence using the Molecular Modeling Database (MMDB), while the quality of the protein model is evaluated using ERRAT. Molecular docking studies are performed using CB Dock server to predict potential binding sites for drug discovery. Structural classification is accomplished using the CATH database, categorizing the protein structure into distinct classes and domains, while exploring Gene Ontology terms associated with GRK2 provides insights into its biological functions. Pathway analysis using KEGG tools explores potential interactions and pathways relevant to cardiovascular disease. This comprehensive approach ensures a thorough investigation of Human GRK2 in complex with G-beta-gamma, offering insights into its structural and functional roles in cardiovascular disease research