Lung cancer is one of the major public health burden amongst cancers as it is currently the most frequently diagnosed major cancer amongst men and 2nd most common overall in the world (estimated 2.21 million new cases in 2020) and the most common cause of cancer mortality worldwide (1.8 million deaths in 2020). In India also it is concerning with ranked 4th overall (2nd in males) amongst all cancers in terms of new cases with the incidence of 5.5% while 5 year prevalence was 5.86 per 1 lakh population. Further, lung cancer caused 66,279 no. of death, compromising of 7.8 percent of all cancer related deaths in India according to GLOBOCAN, March 2021(8) It was a comparative study between these two groups that compared Serum Copper, Serum Zinc and Copper to Zinc ratio. Apart from these, observations were also made on the basis of age, gender and smoking and dietary habits of patients. Amongst our subjects, most patients were of the age group 50-70 years in both early and advanced cases with mean age of 56.41 in early group and 56.71 in advanced group. Most were males with only 3 females in early arm and 1 in advanced. All the 20 patients were vegetarian and smokers. The trend of Cu, Zn and Cu:Zn ratio was more or less same as most of the earlier studies i.e. lower values of serum Cu and Cu:Zn ratio in early lung cancer patients than advanced group while serum zinc level were more in patients of early lung cancer than advanced but the difference between two groups was not found to be significant. In early lung cancer pts, mean S. Cu value was found to be lower (i.e 148.00 ug/dL) than advanced cancer patients (i.e 166.61 ug/dL) with p value 0.234. Mean serum Zinc level in early cancer cases was higher (i.e 134.21 ug/dl) than advanced group (i.e 129.91 ug/dl) with the p value 0.631. Finally, Copper to Zinc ratio was observed which was found to be better indicator of early and advanced lung cancer cases than individual elements as its p value was 0.061 with mean Cu:Zn ratio in early arm was 1.11 while higher in advanced group i.e 1.29. Overall, the difference in levels of S. Copper, S. Zinc and Copper to Zinc ratio early and advanced lung cancer patients was not found to be significant.