ISSN : 2663-2187

CORRELATION OF NEUROTUBERCULOSIS WITH BCG VACCINATION IN CHILDREN-A CROSS SECTIONAL OBSERVATIONAL STUDY

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Dr.Akhilesh Ahirwar, Dr. Samriddhi Jain, Dr.Ananya Ganguly , Dr.Mayur jain , Dr.Rahul Gedam
» doi: 10.48047/AFJBS.6.15.2024.3853-3862

Abstract

Background: Although pulmonary TB is more common, neuro-tuberculosis is the more severe form of tuberculosis, causing death or major neurological sequelae in children despite of treatment Aim: The primary objective of this study is socio-demographic and clinical evaluation of neuro-tuberculosis children and its correlation with the BCG vaccination Materials and methods: Total 45 cconfirmed tuberculosis Children of 6 months-12 years of age presenting with neurological manifestations were enrolled in this study. Detailed socio-demographic history, presenting symptoms, neurological examination and BCG immunization status of the child was documented. All relevant investigation was done in each recruited subject Results: Majority of the children (85.7%) belonged to >5 years of age, predominantly males. No significant association was shown between BCG vaccination and demographic variables (p>0.05). Meningeal irritation and abnormal movements were most common clinical signs of neuro-tuberculosis among BCG vaccinated children and half of them had tubercular meningitis stage 1. HIV status was positive in significantly higher proportion of children with no BCG scar (P<0.05). However, no significant association of BCG scar with Mantoux test and BCG vaccination and mortality in neuro tuberculosis children (p>0.05). Conclusion: Identifying and managing factors responsible for neuro tuberculosis can prevent morbidity and mortality associated with the neuro tuberculosis in children

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