Background: The aim of the study is to prepare nanosuspension in order to improve the dissolution rate and bioavailability of lipophilic fenofibrate. Method: Anti-solvent precipitation followed by sonication technique was adapted, and poloxamer188 was selected as surfactant. This method was selected by using various trails consisting of Solvent to antisolvent volume ratio (1:10, 1:15, 1:20),Amount of stabilizer (30 mg, 40 mg, 50 mg), Stirring speed (800RPM, 1000RPM, 1200RPM) and Sonication time (5 min, 10 min, 30 min, 60 min) etc. Later factorial design was adopted to