Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting the joints, characterized by progressive symmetrical inflammation of the affected joints, leading to cartilage destruction, bone erosion and disability. Quercetin is one of the most important bioflavonoids known for its anti-inflammatory, anti-hypertensive, vasodilator, anti-obesity, anti-cholesterol and anti-atherosclerosis effects. The use of the drug is largely limited by its low hydrophilicity, so the present study improves its solubility by adding ethanol. Local use of high concentrations of ethanol is not recommended due to the risk of local irritation. Therefore, a suitable quercetin carrier for effective topical application is necessary for the treatment of rheumatoid arthritis. The use of quercetin is largely limited due to its low hydrophilicity. The aim of this study is to investigate the possible use of emulsomes to deliver quercetin in the treatment of rheumatoid arthritis.Emulsomes provide an effective topical drug delivery system due to the high retention flux and high skin retention of the drug, resulting in increased antifungal activity and reduced skin irritation. The characterization of the prepared emulsomes was performed using PDI index, zeta potential measurement, capture efficiency, etc. The pH, extrudability, dispersibility, roughness, viscosity, adhesion efficiency, etc. of the emulsome gel were checked.Emulsomes containing phosphatidylcholine (soy lecithin) cholesterol and or solid lipid were prepared and optimized for lipid ratios.. The solubility of the drug in 0.1N HCl and phosphate buffer pH 7.4 was found to be 0.0276 and 0.0094 mg/ml in different solvent respectively. The results of gel formulation having pH range 7.2 to 7.8 are desirable to skin pH, since they do not interfere with the physiology of skin.