Ofloxacin is a synthetic broad-spectrum antimicrobial agent for oral administration. Ofloxacin is considered to be soluble in aqueous solutions with pH between 2 to 5. It is sparingly to slightly soluble in aqueous solutions with pH 7 (solubility falls to 4 mg/ml). The molecule exists as a zwitterion and precipitation of active compound occurs in small intestine which adversely affects absorption. Conventional formulations of Ofloxacin can not maintain required plasma concentration for long time and is therefore given 3-4 times a day also it shows greater dose dependent side effects. So need to formulate such drugs into desirable drug delivery systems. This study investigated utility of a 3-factor, 3-level Box-Behnken design and optimization process for floating tablet. Amount of HPMC, amount of NaHCO3 and amount of citric acid were selected as the independent variables whereas total floating time (TFT), T50%, % CR10hrs, and diffusion coefficients (n) were selected as dependent variables. The prepared tablets of Ofloxacin were evaluated for dissolution study and found to follow zero order release kinetic. The responses were analyzed using ANOVA and the individual response parameters were evaluated using F test and polynomial equation was generated for each response using multilinear regression analysis (MLRA). The amount of HPMC and amount of citric acid were found to significantly influence all response parameters selected whereas the amount of NaHCO3 has significant effect on TFT.