Diacerein is a one-of-a-kind drug that was created to help osteoarthritis by reducing inflammation and pain and lowering body temperature. The study's main goal was to create and test Diacerein microspheres with controlled release qualities, with egg albumin as the main ingredient. Spreading under control The dicerein nanoparticles were made using a chemical cross-linking method that used different amounts of a natural polymer, like egg albumin. The shape, drug content, entrapment effectiveness, and anti-inflammatory action in vitro of the microspheres that were made were all tested. Including microspheres of F3 in a formulation led to the best drug release, entrapment efficiency, amount of in vitro drug release, and enough anti-inflammatory action.