This study investigates the physicochemical properties, formulation optimization, and stability of Ipriflavone nanoemulsions aimed at enhancing its therapeutic efficacy in osteoporosis treatment. Ipriflavone, characterized as a white to off-white crystalline powder with a melting point of 172–175°C, exhibited favorable flow properties with a bulk density of 0.58 g/cm³, tapped density of 0.46 g/cm³, compressibility index of 13.79%, and a Hausner ratio of 1.16, indicating moderate flowability. Five nanoemulsion formulations (NS-1 to NS-5) were evaluated for drug loading efficiency, yielding values ranging from 43.47% to 48.88%, with NS-3 achieving the highest yield at 75.32%. Particle size analysis revealed that NS-1 had a particle size of 436 nm, while NS-5 demonstrated the smallest size at 251 nm, correlating with improved stability. Spreadability and viscosity assessments indicated that NS-5 provided optimal ease of application (5.8 g•cm²/sec) and acceptable viscosity (8125 cps). A three-month stability study at 30 ± 2°C and 75 ± 5% relative humidity confirmed that the optimized ocular insert formulation maintained its appearance and drug content, slightly decreasing from 93.15% to 93.05%. These results underscore the potential of Ipriflavone nanoemulsions for effective delivery systems, providing a foundation for future clinical applications.