ISSN : 2663-2187

Development and evaluation of risperidone-loaded solid lipid nanoparticles

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Uvaraja VC, C.M. Jamkhandi, Vandana R. Daga, Ramana Gangireddy, Keshamma E, Rajeev Ramachandra Kolgi, Chetan D.M., Uddappanda Bopaiah Roy
» doi: 10.48047/AFJBS.6.14.2024.1822-1832

Abstract

Solid lipid nanoparticles are a potential way to deliver drugs. They are made up of solid lipids, surfactants, and active drug molecules. The study's goal was to look at the physicochemical features and see how the drug was released. The present study is an attempt to make stable lipid nanoparticles of risperidone using a mix of polymer and lipid components. from the fact that the tests always came up with the same results. The infrared spectra showed that the polymer and risperidone did not interact with each other, which proved that the two molecules are compatible. We made risperidone solid lipid nanoparticles using the solvent injection method, which involved mixing glyceryl monostearate and tween 80 in water to make an emulsion. It was found that increasing the concentration of lipids made the solid lipid nanoparticles better at catching things. Formulation F3 was able to trap 77±0.3% of its targets. The study of the particle sizes of the solid lipid nanoparticles made with risperidone shows that all of the particles in the mixtures were in the nano range. Particles with a size of 278.6 nm were found to be the smallest in tests F3 and F4. A study on drug release that was done in a lab found that adding more lipids also makes the medication break down faster. The results of the dissolving study made it hard to believe that solid lipid nanoparticles could control how quickly the medicine risperidone was released. The current study comes to the conclusion that the dissolving test made it hard for solid lipid nanoparticles to control how fast the drug risperidone was released. Keywords: Risperidone, solid lipid nanoparticles, drug delivery, solubility.

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