Objective: The objective of present research work was formulating and evaluating topical gels containing T. patula flower, Permoterma reticulatum lichen, and Curcuma caesia (Root hairs) extracts for the treatment of acne. Methods: The phytochemical composition of the plant extracts was determined. The extracts and gels' minimum inhibitory concentration (MIC) was assessed using the microbroth dilution method. The marker compound, clindamycin, in herbal anti-acne preparation, was kept for the comparison with the zones of inhibition for antibacterial activity. All the prepared topical gel formulations were evaluated using 1% Carbopol 940 as a gelling agent and were used different ratio of T. patula flower, Permoterma reticulatum lichen, and Curcuma caesia (Root hairs) extracts.