Over‑the‑counter energy boosting agents tablet formulation consist of L-carnitine and caffeine and garciniacumbogia one of the common used. In this research paper we have proposed RP-HPLC method for L-carnitine and Caffeine in synthetic mixture combination. As both the drugs shows synergistic effect as a energy boost which additionally used to reduce triglycerides level with no harmful effect on lipid profile.The HPLC method employed at thermo scientific, hypersil C18column (250mm× 4.6mm, 5μm) with an isocratic mixture of acetonitrile and water (20:80 v/v) as the mobile phase. The column temperature was kept at 30°C.The flow rate was1.0 mL/min and detection was by means of a UV detector at wavelength of 252 nm. Both the components were successfully eluted with mean retention times of 3.2 min &4.5 min for caffeine &L-carnitine respectively. The method was found to be linear (R2> 0.99), precise (RSD < 0.7 %), accurate (recoveries 97.9–100.8 %), specific, simple, sensitive, rapid and robust. The validated method can be used in routine quality control analysis without any interference by excipients.