Cushing’s syndrome or hypercortisolism refers to the excess secretion of glucocorticoids from any sources, whereas Cushing’s disease (CD) refers to hypercortisolism due to pituitary adenoma causing excess secretion of adrenocorticotropic hormone (ACTH). It is rare in paediatric population and confirming diagnosis of Cushing’s Disease can Key words: - become quite challenging in some cases. Hypercortisolism is associated with high morbidity and mortality, largely due to cardiovascular diseases. Here we present a case of an adolescent female patient who presented with a two- year history of excessive sweating, joint pain, headaches, hirsutism,acne, weight gain and muscle cramps.