Typhoid fever, a well-known enteric disease caused by bacteria from the Salmonella species, poses a significant threat to public health. The accuracy of diagnostic tests for typhoid fever can vary, with widely used methods such as the TUBEX-TF, Typhidot, and Widal tests producing inconsistent outcomes. These tests often show differences in sensitivity and specificity based on the region and population being tested. This review assessed the diagnostic reliability of various rapid diagnostic tests (RDTs) for typhoid fever in regions such as Zimbabwe, Bangladesh, India, Indonesia, Cameroon, and others. A comprehensive literature search was conducted using databases like PubMed and Google Scholar to identify relevant studies published between 2015 and 2024. Studies assessed tests like TUBEX-TF, Typhidot, Widal, and newer systems such as the DPP Typhoid System. Results showed significant variability in sensitivity and specificity across regions, with TUBEX-TF showing sensitivities from 24% to 97.6% and specificity up to 99%, while the Widal test demonstrated high sensitivity but low specificity in some areas. Bayesian Latent Class Models were applied in several studies to refine accuracy assessments. The findings suggest that no single test is consistently reliable across all settings, and a combination of diagnostic approaches or the use of newer systems may improve accuracy. Further research is needed to validate the performance of emerging tests in diverse populations.