Introduction: This study aims to evaluate the diagnostic accuracy of plain brain CT scans compared to contrast-enhanced CT scans for identifying meningitis. It focuses on determining the effectiveness of both imaging techniques in detecting the condition. The comparison will provide insights into which method is more reliable for diagnosing meningitis. Objective: To find the diagnostic accuracy of plain brain computed tomography with contrast enhanced in the diagnosis of meningitis. Materials and Methods: A cross-sectional study was carried out at Hamid Latif and Shalamar Hospital in Lahore, involving 42 participants selected through a suitable sampling method. Data analysis was performed using MEDCALC software. The inclusion criteria included patients with clinical suspicion of meningitis, symptom onset within the previous 72 hours, and symptoms such as fever, headache, neck stiffness, or altered mental state. The exclusion criteria comprised patients with symptoms lasting over 72 hours, those with open cranial malformations, patients. Results: Among the 42 patients included in the study, the average age was 1.2 years. The findings indicated that contrast-enhanced CT provided greater diagnostic accuracy. Of the 42 patients, 32 were diagnosed with meningitis, while 10 did not have the condition. Analysis of CSF variables as a diagnostic classifier suggested limited capability in differentiating positive and negative infarction cases, good capability for identifying positive and negative cases of ventriculomegaly, and limited effectiveness in detecting midline shift, meningeal enhancement, and edema.