This research evaluates the extracts of Punica granatum, Malus domestica, Vitis vinifera, and Citrus sinensis for their total phenol content, antioxidant capacity, and in-vitro anti-leukemic activity. On the basis of phytochemical analysis, it was found that P. granatum extract has the highest level of total phenolics, flavonoids, and tannins. From the FTIR spectroscopy, all the extracts contained different functional groups. DPPH, ABTS, superoxide, and nitric oxide scavenging actions holistically showed P.granatum extract as the most potent radical scavenging, followed by V.vinifera, M.domestica, and C.sinensis. These studies have demonstrated significant associations between the antioxidant activity and phytochemical concentration. THP-1 and HL-60 anti-leukemic activities showed that all fruits inhibited the cell growth in varying degrees; the highest significant percentage was provided by P.granatum. These outcomes present the perspective of these fruit extracts, primarily P.granatum, as sources of organic antioxidant and anti-leukemic components. Most of these plants have not been fully explored on their utilisation in medication and the way they work.