Background: PPH may occur due to failure of uterine contraction after delivery and subsequently leading to loss of 500 ml or more blood during vaginal delivery and 1000 ml or more during cesarean delivery. Misoprostol is prostaglandin can be given by oral, vaginal, sub lingual and rectal route. Its dose may vary from 200 μg to 1000 μg. Aim: To compare the efficacy and side effects of 3 sublingual dose of Misoprostol for prevention of PPH. Methodology: The present interventionstudy was conducted to compare the effectiveness of sublingual misoprostol 3 dose for prevention of post-partum haemorrhage in patient with caesarean delivery. A total 60 subjects were divided into 3 groups namely M400, M600, and M 800. M400 group received 400ug of sublingual Misoprostol, M600 group received 600ug of sublingual Misoprostol and M800 received 800 ug of sublingual Misoprostol immediately after opening the peritoneum. Result: The lowest mean blood loss was seen in the patients who received 800μg Sublingual Misoprostol, followed by 600μg and 400μg Sublingual Misoprostol. In 10.0% case in 400μg and 5.0% case in 600 μg and 800 μg Sublingual Misoprostol group, total blood loss was >1000ml. There was significant lower duration of 3rd stage of labour in 800μg dose of Sublingual misoprostol in comparison to 400 ug& 600ug sublingual Misoprostol. In 400μg Sublingual Misoprostol 5.0% cases needed one unit and 5.0% cases needed more than one unit blood transfusion. The increased incidence of side effects like shivering, fever, Abdominal Pain, Nausea &vomiting, Hypotension and Tachycardia was more with increased dose of sublingual misoprostol. Conclusion: The lower doses of misoprostol may be as effective as high doses in term of total blood loss and loss of hematocrit level as there was no significant difference between 3 sublingual dosages of misoprostol.Clinical applications of low doses of sublingual misoprostol for the prevention of PPH should be further explored by large randomized trials comparing the effectiveness and the safety of low doses of sublingual misoprostol.