Drug-induced liver injury (DILI) remains a critical concern in clinical practice, leading to significant morbidity and mortality. This study delves into the mechanistic insights, hepatic structural alterations, histopathological patterns, and management approaches associated with DILI. The objective is to elucidate the underlying mechanisms by which various pharmacological agents induce liver injury, characterize the resultant hepatic structural and histopathological changes, and evaluate current management strategies.