Background: Bilateral superficial cervical plexus block (BSCPB) can be used as preoperative analgesia or to manage postoperative pain in surgery cases. Interleukin-6 (IL-6) is the most relevant marker of tissue damage during surgical procedures and is an important and accurate biomarker of pain. This study aims to determine the effects of bilateral superficial cervical plexus block (BSCPB) on IL-6 levels in patients undergoing ishmolobectomy. Methodology: The research employed a quasi-experimental design. Samples were divided into two groups: an intervention group (levobupivacaine 0.25%) and a control group (NaCl 0.9%). Results: Patients receiving BSCPB with levobupivacaine 0.25% showed a decrease in the average IL-6 levels, which were lower than those of patients receiving NaCl 0.9%. Levobupivacaine 0.25% significantly affected IL-6 levels at 6 and 12 hours post ishmolobectomy (p<0.05). Conclusion: BSCPB with levobupivacaine 0.25% in ishmolobectomy patients has a positive effect on pain management by reducing IL-6 levels, thereby accelerating recovery. There is a need for extended follow-up to assess long-term effects.