Background: CS exposure is a source of health problems including reproductive health. CS triggers imbalances that lead to cell abnormalities to cell functional disorders. The purpose of this study was to prove the effect of BG extract on the reproductive organs of rats exposed to cigarette smoke. Method: This research has a true experimental design with samples consisting of female Wistar rats. The interventions carried out are rats were exposed to cigarette smoke 2 cigarettes daily for 28 days, then given Bg extract at doses of 50, 100, and 200 mg / kg BB. After receiving the intervention, data tabulation was carried out by assessing ovarian NO levels, follicle measurements, and observing ER-α Expression and Caspase Expression 3 IHC Method The data obtained were carried out parametric prerequisite analysis, then tested the difference between One Way Anova and Post Hoc. Data processed with SPSS for windows 26. Results: exposure to cigarette smoke can reduce ovarian NO levels, healthy follicles, Erα expression, and increase caspase 3 expression, black garlic extract administration can improve the condition. Conclusion: Black garlic extract is able to improve abnormal conditions caused by exposure to cigarette smoke on reproduction