The tomato (Lycopersicon esculentum), a member of the Solanaceae family, is a widely cultivated vegetable known for its nutritional and therapeutic properties. Heavy metal (HM) contamination of soil has become a significant problem for the modern world as a result of the quick modernization and development of agricultural sectors as well as the growth of chemical industries. Low concentrations of heavy metals (HMs), which are high-density transition metals, can be hazardous. The purpose of this study was to explore the effects of cadmium (Cd) on some physicochemical characteristics and bioactive compounds of Lycopersicon esculentum. L. esculentum plants were grown in pots containing 3 kg of air-dried sandy loam soil and treated with different concentrations of cadmium at doses 25, 50, 75 and 100mg/kg. It was observed that there was a progressive increase in the total soluble solids (TSS) and Titrable acidity (TA), while the fruit pH decreased significantly on treatment with higher doses of Cd. Tomato plants showed declines in germination percentage, survival percentage, plant height, root length, average number of fruits, and fruit weight, all to varying degrees. By contrast, the ascorbic acid content, total phenols, flavonoids, total reducing sugars had rising effects under the influence of Cd toxicity. The lycopene content presented no standard response, decreasing and even increasing according to Cd concentrations.