Background: Hemodynamic response to intubation always remains a cause of concern for anesthesiologists particularly in patients undergoing cardiac surgeries where sympathetic stimulation could prove to be detrimental for patients. Keeping in view the advantage of Video laryngoscopy we compared C Mac video laryngoscope with Macintosh laryngoscope to evaluate the hemodynamic alteration and efficacy in patients posted for cardiac surgeries. Methods: Sixty adult patients posted for various cardiac surgeries were divided into two groups using computer‐based randomization, and tracheal intubation was performed using either C Mac video laryngoscope or Macintosh laryngoscope. The primary outcome measures were hemodynamic response to intubation. Incidence of successful tracheal intubation in first attempt, duration of intubation and glottic view (percentage of glottis opening-POGO) and airway complications were also compared. Results: Haemodynamic response to intubation was significantly more in Macintosh group when compared to C-Mac group. Intubation time was significantly shorter with Macintosh laryngoscope (15.3 vs. 20.8 s; P < 0.001). Both groups were comparable in terms of incidence of successful tracheal intubation in first attempt and POGO scoring. Conclusion: Although statistically C-Mac Video Laryngoscope causes significantly lesser hemodynamic alteration as compared to Macintosh laryngoscope, the haemodynamic response was well within 20% of baseline values with both the devices.