Background: Cancer is a life threatening illness and its treatment affects the entire life of the affected children and deteriorates their Quality of life (QoL). Aim of the present study: was to evaluate the effect of educational program on quality of life among children receiving chemotherapy. Subjects and Methods: a quasi-experimental study was conducted on a purposive sample of 58 children receiving chemotherapy at oncology unite of university children hospital and oncology unite and in internal Medicine hospital at Zagazig University Hospitals . Tools for data collection :Tow tools were used to collect necessary data as follows :structure questionnaire form and Quality of Life Inventory-32 (PCQL-32) . Results :The current study revealed that 56.9%of the studied cancer children had bad quality of life symptom level before the educational program and this percentage decreased to 19.0% after implementation of the educational program. Poor quality of life among cancer children receiving chemotherapy may be due to treatment impact on children physical, psychological, and social well-being. Conclusion: The educational program had positive effect on improving quality of life scores among studied children. Recommendations :Dissemination of the educational program to other pediatric oncology hospitals, with involvement of other family members in the program is recommended.