Buxus microphylla 'Golden Dream' is widely cultivated for its compact growth habit, glossy foliage, and golden-yellow new growth, making it a popular choice for landscaping and horticulture. A pot experiment was conducted during the 2021 and 2022 seasons in a heated plastic house belonging to the Nursery of Duhok University, located on the Zanko campus. The aim of this study was to investigate the effect of foliar application of Nano NPK fertilizer at concentrations of 0, 2, and 4 g l-1 and 2,4-D at concentrations of 0, 100, and 200 mg l-1 on the growth and development of Buxus plants. The results showed that the application of these two factors had a significant impact on most of the vegetative growth parameters, including plant height, longest branch length, growth index, number of branches and leaves per plant, leaf area, and root dry weight. The highest recorded values were obtained in plants treated with Nano NPK fertilizer at a concentration of 4 g l-1, which had a plant height of 40.67 cm, longest branch length of 36.00 cm, growth index of 2747.4 cm³, number of branches of 6.56 branch plant-1, number of leaves of 115.22 leaf plant-1, leaf area of 1126.3 cm², and vegetative and root dry weight of 14.72-5.38 g. However, plants sprayed with high concentrations of 2,4-D at 200 mg l-1 achieved the highest values for plant height 36 cm, growth index 2684.2 cm³, number of branches 5.78 branch plant-1, number of leaves 87.44 leaf plant-1, leaf area 869.6 cm², and vegetative and root dry weight 13.31-5.78 g. Furthermore, the best interaction between the two factors was observed when high levels of nano NPK fertilizer 4 g l-1 were combined with 2,4-D at a concentration of 100 mg l-1, which led to increased vegetative parameters. These findings suggest that this combination could be a promising treatment for enhancing the growth and development of Buxus plants in horticultural applications.