Background:Owing to the drawbacks that occurs due to the long periods of orthodontic treatment, such as the development of white spot lesions, root resorption, and periodontal disease, accelerated orthodontic tooth movement is a paramount objective of the contemporary orthodontic community. Major orthodontics industries invest in new innovations that claim that they reduce the resistance to friction between orthodontic archwires and brackets, thus the treatment duration. One of the methods to improve archwire properties and reduce the resistance to friction during sliding mechanics is to coat the archwire with different materials. The introduction of nanotechnology in the medical and dental industries allows the use of different types of materials in a manner that allows manufacturers to coat wires with different materials to obtain different properties. The aim of the studywas to determine whether zirconium dioxide nanoparticles coated orthodontic appliances demonstrate a higher rate of tooth movement during a single canine retraction procedure than a non-coated orthodontic appliance. Material & method: This study was a split- mouth randomized control trial. It was carried on twenty-one patient with forty-two canines were retracted. They were randomly divided into three cohorts; each cohort contained a side that was randomly selected as either the control or study side. Cohort A: the study was (coated wire and coated brackets). Cohort B: the study side was (coated wire and uncoated brackets). Cohort C: the study side was (uncoated wire and coated brackets). All patients were fitted in a selective criterion. Digital scans were taken at each visit, and superimposition was performed using Medit Design® software. The rate of canine retraction per visit was measured. Results: (Cohort A) showed a statistically significant difference between (control) and (study) sides where the highest mean value was found in (control) side. (Cohort B): There was a significant difference between control) and (study) sides with highest mean value was found in (study) side. (Cohort C): There was a significant difference between (control) and (study) groups with the highest mean value was found in (control) side. There was a statistically significant difference between (Cohort A), (Cohort B) and (Cohort C) (p value <0.001). A statistically significant difference was found between (Cohort A) and each of (Cohort B and C) (p value =0.001) and (p value <0.001) respectively. In addition, a statistically significant difference was found between (Cohort B) and (Cohort C) (p value <0.001). The highest mean value was found in (Cohort B), while the lowest mean value was found in (Cohort A). Conclusion: These results suggest that zirconia coated nickel titanium orthodontic archwires increased the rate of canine retraction compared to the non-coated appliance. Unexpectedly, in clinical practice, coating both archwires and brackets acted negatively and reduced the rate of canine retraction.