Background: This study investigates the impact of chronic stress on salivary gland function and oral health status, specifically analyzing salivary flow, pH, protein content, and oral health status indices such as xerostomia, dental caries, and gingival inflammation. The study aims to explore the correlations between varying levels of stress and deteriorating oral health status. Methodology: A study was conducted from January 2023 to January 2024 at Sardar Begum Dental College and Hospital, Peshawar. This cross-sectional study involved 250 participants. Stress levels were assessed using validated questionnaires, while salivary flow rates, pH, and total protein levels were measured using standard biochemical assays. Oral health status was evaluated through the DMFT (Decayed, Missing, Filled Teeth) index, xerostomia scores, gingival index, and plaque accumulation. Data were analyzed using ANOVA to identify significant differences among stress groups. Results: Significant reductions in both unstimulated (0.45 mL/min to 0.20 mL/min) and stimulated (1.15 mL/min to 0.55 mL/min) salivary flow rates were observed as stress levels increased (p < 0.05). Salivary pH dropped significantly (p = 0.002), while total protein levels increased (p < 0.001). Similarly, oral health status deteriorated with rising stress levels, with higher xerostomia scores, DMFT index, and plaque accumulation (p < 0.001). Conclusion: Chronic stress is associated with decreased salivary gland function and worsening oral health status. Integrating stress management into oral health status protocols may help mitigate these effects, particularly in high-stress populations.