Background: Garlic (Allium sativum) has been traditionally used for its potential health benefits, particularly in the management of cardiovascular and metabolic conditions. This study investigates the effects of garlic supplementation on glucose parameters and lipid profiles in patients. Objective: To evaluate the impact of garlic supplementation on blood glucose levels and lipid profiles in a sample of 285 patients. Methodology: This randomized control trial (RCT) was designed to assess the effects of garlic supplementation on glucose parameters and lipid profiles in patients with metabolic abnormalities. A total of 285 patients with varying degrees of glucose and lipid profile abnormalities were selected for the study. These abnormalities included elevated fasting blood sugar, HbA1c, total cholesterol, LDL cholesterol, and triglyceride levels. Results: The study evaluated the effects of garlic supplementation on glucose parameters and lipid profiles in 285 participants with varying degrees of metabolic abnormalities. The garlic group showed a significant reduction in fasting blood sugar and HbA1c levels compared to the placebo group after 12 weeks. Fasting blood sugar dropped by 16.8 mg/dL in the garlic group, compared to only 2.7 mg/dL in the placebo group. Similarly, HbA1c decreased by 0.6% in the garlic group, while the placebo group saw a minimal decrease of 0.1%. These results suggest garlic may have a notable impact on improving blood sugar control. Conclusion: Garlic supplementation appears to positively affect glucose parameters and lipid profiles in patients, suggesting its potential role as an adjunct therapy in managing diabetes and hyperlipidemia.