The purpose of this study was to determine the efficiency of weed control herbicide mixture Penoxsulam + Butachlor in transplanted rice. The research was conducted in Jombor Village, Sewon District, Bantul Regency, Yogyakarta Special Region, in September - December 2022 A single-factor trial, with a complete randomized group design. As treatments are Penoxsulan + Butachlor 410 SC dose 410 gai / ha (D1), dose 512.5 gai / ha (D2), dose 615 gai / ha (D3), dose 717.5 gai / ha (D4), dose 820 gai / ha (D5) dose 1,025 g ai / ha (D6) and comparison herbicide penoksulam 25 g / I dose 15 gai / ha (D7), ethyl pirazosulfuron 10 % dose 6 gai / ha (D8), Oxadiargyl 600 g/l dose of 18 gai/ha (D9), triasulfurom 75% dose 11.3gai/ha(D10), Tiobencarb 4% and 2.4 D ipa 2% dose 1200 g ai/ha(D11) and without treatment (D12). The results showed that (1) Application of Penoxsulam + butalachlor herbicide did not show phytotoxicity in rice plants. (2) Penoxsulan+Butachlor herbicide starting at a dose of 410 g ai/ha has good effectiveness for controlling F. miliace, C. difformis, M. vaginalis, C. iria, and M. minuta. While weeds E cruss-galii and S. zeylanica were very effectively controlled starting at a dose of 615 gai / ha and L. cinensis was very effectively controlled starting at a dose of 717.7 gai / ha. Penoxsulan+Butachlor starting at a dose of 717.5 gai/ha effectively controls L. octovalvis.