Klebsiella pneumoniae is a gram negative, that causes several health implications like inflammation in lungs (bacterial pneumonia), meningitis, UTI, intra-abdominal infection etc. The aim of current study is to depict the multidrug resistance induced by various classes of efflux pumps attributed to K.pneumoniae strains and the bacteria accommodates profuse number of efflux pumps like RND, SMR, ABC, MFS etc. It has the ability to export a broad range of toxic compounds into the external environment from within the bacterial cell, including many kinds of antimicrobial drugs. This study also gives brief description on efflux pump inhibitors like reserpine, phenylalanine-arginine β-naphthylamide (PAßN), flavonoids, piperine, carbonyl cyanide-chlorophenylhydrazone (CCCP), etc. These pumps are capable of extruding a wide variety of antibiotics, and they are often enhanced due to mutations in regulatory genes such as ramR and acrR. Targeting these pumps with EPIs has the potential to refine the efficiency of accessible antibiotics and address the global challenge of antibiotic resistance faced by this powerful disease. Nevertheless, efflux pump inhibitors (EPIs), which may be found naturally or artificially, have shown promise as potential therapies for K. pneumoniae, a bacteria that is resistant to several drugs.