Cassava is a crucial food crop with significant economic and nutritional importance, particularly in tropical regions. Despite its potential, cassava yields remain insufficient in Côte d’Ivoire, largely due to poor cultivation practices such as inappropriate planting densities. This study investigates the impact of sowing density, location, and variety on cassava production in the Vavoua department of central-western Côte d’Ivoire. The research focused on two cassava varieties, Yavo and Bonoua, grown under three planting densities (1m x 80 cm, 1m x 1m, and 80 cm x 80 cm) at two locations, N'Guessankro and Sanpedro2. Results indicate that the Yavo variety achieved the highest yield when planted at a low density (1m x 1m) in N'Guessankro, benefiting from favorable environmental and soil conditions. Optimal spacing facilitated efficient resource use and enhanced photochemical activity, boosting cassava growth and yield. Conversely, close planting led to increased competition for nutrients, limiting productivity. The findings underscore the importance of selecting appropriate planting density, variety, and location to maximize cassava productivity. Further studies are recommended to explore the impact of organic fertilizers and their optimal application rates on cassava yields in this region.