Background: Post-prostatectomy urinary incontinence (PPUI) is a significant complication following prostatectomy for benign prostatic hyperplasia and prostate cancer, impacting patients' quality of life. This study aims to analyze epidemiological trends and evaluate the effectiveness of various preventive measures and surgical interventions for managing PPUI. Methods: A systematic review and network meta-analysis (NMA) were conducted by retrieving data from PubMed and the Cochrane Library up to August 2021. Randomized controlled trials on surgical treatments for PPUI, including artificial urinary sphincter (AUS), adjustable slings, nonadjustable slings, and bulking agent injections, were included. The NMA assessed treatment efficacy using odds ratios and 95% credible intervals (CrIs) for achieving urinary continence, pad weight, pad use, and International Consultation on Incontinence Questionnaire scores.