Introduction: Pancreatic cancer is a highly fatal disease with a 5-year survival rate of approximately 10% in the USA, and it is becoming an increasingly common cause of cancer mortality. EUS is the most suitable modality for detection of pancreatic lesions due to its spatial resolution. CT is considered the gold standard for pancreatic cancer diagnosis. The typical CT appearance of a PDAC is an ill-defined hypoattenuating mass within the pancreas. Smaller lesions may be iso-attenuating, making difficult their identification. Aim of the work: evaluate and compare between EUS and CT in evaluating pancreatic masses. Results: This study confirmed superiority of EUS in assessment of nature of pancreatic masses. Conclusion: EUS is better than CT in detection and assessment of pancreatic lesions.