This study analyzed bacterial infections and histological changes in skinburn wound infections, in order to evaluate their histological change and antimicrobial susceptibilities. Out of 100 burn wound cases admitted to surgery department, Pseudomonas aeruginosae as the most common organism followed by Staphylococcus aureus, Escherichia coli and Klebsiellapneumoniae etc. However, all the staphylococci were susceptible to Vancomycin and the gram negatives were susceptible to Imipenam. For empiric treatment, Vancomycin and Imipenem appear to be a good combination in this hospital. The histopathological changes during the distinctive phases of burn wound is correlates the bacterial infections and their antibiotic susceptibilities. Although medical centers have devoted intensive resources to improving the survival rates of burn patients with bacterial infections. This study may contribute to the establishment of a nationwide burn database and the elaboration of strategies to control burns wound infections.