the present study was conducted with the aim of investigating the effectiveness of REPs in adult teeth with pulp necrosis. Method: all international databases, PubMed, Scopus, Science Direct, ISI, Web of Knowledge and Embase were examined, until March 2023 based on keywords related to the objectives of the study. The current study was conducted based on the PRISMA 2020 checklist, and Google Scholar search engine was also used to find related articles. The 95% confidence interval risk ratio was calculated using the fixed effect model. Stata/MP v.17 software was used to conduct the meta-analysis. Result: After reviewing the abstracts of 181 articles, 32 articles were selected for full text review, of which three articles were included in the meta-analysis. Risk ratio of successful treatment outcome between regenerative endodontic procedures group and nonsurgical root canal treatment group was 0.05 (RR, 0.05 95% CI -0.05, 0.15; p>0.05). significant difference between regenerative endodontic procedures group and nonsurgical root canal treatment group in terms of positive response to electric stimuli (RR, 1.59 95% CI 0.60, 2.59; p>0.05). Conclusion: Based on the present meta-analysis, regenerative endodontic procedures are a favorable treatment method compared to traditional methods in the treatment of necrotic adult teeth.